Value of Octopus Automated Perimetry in Patients on Hydroxychloroquine Treatment

Hydroxychloroquine retinopathy is a well-known toxic manifestation of a commonly used systemic medication. The aim of this study was to evaluate the role of automated perimetry in detecting early retinal involvement related to hydroxychloroquine therapy. The study group was made up of 25 patients (21 females and four males, average age 34.5 years) affected by rheumatological diseases treated with hydroxychloroquine. All patients underwent an ophthalmological examination and computerized perimetry (Octopus 2000R), using a static Full Threshold Program (31 Program) prior to and 12 and 18 months after treatment. For visual field evaluation, the authors considered perimetric indices (MD: mean defect) and the presence of scotomas, in relation to their depth and extension. They discuss perimetric defect variations in relation to dose of drug used and duration of therapy. The results confirm the sensitivity of Octopus perimetry in determining the first signs of hydroxychloroquine retinal toxicity and its important role in the follow-up of patients using this drug.